The cathedral was founded in 1612 at the expense of the richest Orthodox citizens and nobility of Minsk province. During wars and religious conflicts the church was used as a fortress on numerous occasions. This is why its walls are so thick and have loopholes in them, and the windows are so high above the ground. The cathedral was visited by Emperor Paul I. A venerated icon of martyrs Anthony, John, and Eustathius of Vilnius with particles of their relics is kept at the cathedral.