The church has long been the only Orthodox Church in Minsk. During wars and religious conflictsthe church made a defensive role, becoming a fortress. This is due to the thickness of the walls, the high location of the windows above the ground and the presence of loopholes.

The Church, which, before the XIX century was the Orthodox cathedral, was visited by the Emperor Paul I. During the War of 1812, the church hosted a French hospital. During the Second World War, the church served as a refuge from the bombing of the citizens. Until the early 1990s, the building was the archive, since 1991 in the service of the church was renewed.

On 6 April 1999, eight new bells were sanctified and raised to the belfry. In January of 2001, their number was complemented by another one, the biggest.

The revered icon of Vilna Martyrs Anthony, John and Eustace with particles of relics is kept in the church.